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US 12,767,637 B2Granted
Mitochondrial targeting compounds for the treatment of associated diseases
AssigneeThe Regents of the University of Michigan
InventorsNouri Neamati, Ding Xue, Yibin Xu
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Abstract
Mitochondrial targeting compounds for the treatment of cancer and other disorders associated with mitochondrial function, including diabetes, autoimmune diseases, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases and their preparation. The present invention is also directed to the pharmaceutical compositions and treatment methods, prodrugs based on those compounds and the use thereof.
Claims2
A compound described by
- or a pharmaceutically acceptable form thereof;
- wherein R1 is selected from the group consisting of:
- and CH3;
- wherein R2, R4, and R6 are independently selected from the group consisting of:
- hydrogen,
- wherein R3 and R5 are independently selected from the group consisting of:
- hydrogen
- wherein four of R2, R3, R4, R5, and R6 must be hydrogen.
5 more elements
Dependencies are inferred from the claim text.