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US 12,766,485 B2Granted
Immunoglobulin-binding protein variants with increased alkali-tolerance and use thereof
AssigneeAmicogen, Inc.
InventorsSu Lim Choi, So Young Park, Sol A Park, Yeo Won Sim
Life of this patent
Estimating the term…
Abstract
Provided are immunoglobulin-binding protein variants with increased alkali tolerance, and uses thereof, and more particularly to immunoglobulin-binding protein variants with increased alkali tolerance relative to the wild type due to mutations in amino acids at specific positions in the B3 domain of the immunoglobulin-binding proteins.
Claims18
A polypeptide comprising SEQ ID NO:4, wherein the first amino acid (Met, M) is optionally absent, and wherein beginning from a proline (Pro, P) which is the second amino acid in the amino acid sequence of SEQ ID NO:
- 4, the 28th amino acid (glutamic acid (Glu, E)), is substituted with an amino acid selected from the group consisting of glycine (Gly, G), alanine (Ala, A), leucine (Leu, L), proline (Pro, P), and tryptophan (Trp, W).
Dependencies are inferred from the claim text.