Back to results
US 12,766,316 B2Granted
Implantable piezoelectric scaffold and exercise-induced piezoelectric stimulation
AssigneeUniversity of Connecticut
InventorsThanh Duc Nguyen, Yang Liu
Life of this patent
Estimating the term…
Abstract
An implantable scaffold is provided including multiple piezoelectric films and at least one compressible intervening layer. A first of the piezoelectric films is on a first side of the compressible intervening layer and a second of the plurality of piezoelectric films is on a second side of the compressible intervening layer opposite the first piezoelectric film. Upon applying a mechanical force to the first piezoelectric film, the first piezoelectric film deforms towards the second piezoelectric film. Also provided is a method of treatment leveraging the implantable scaffold.
Claims13
An implantable scaffold comprising:
- a plurality of piezoelectric films;
- and
- at least one compressible intervening layer,
- wherein a first of the plurality of piezoelectric films is on a first side of the compressible intervening layer and a second of the plurality of piezoelectric films is on a second side of the compressible intervening layer opposite the first piezoelectric film,
- wherein upon applying a mechanical force to the first piezoelectric film, the first piezoelectric film deforms towards the second piezoelectric film,
- wherein the plurality of piezoelectric films are biodegradable and wherein the implantable scaffold does not comprise a battery,
- wherein each of the plurality of piezoelectric films comprise at least one of poly (L-lactic acid) (PLLA), silk, polyglycine, or collagen, and wherein each of the plurality of piezoelectric films are manufactured by electrospinning,
- wherein the plurality of piezoelectric films are manufactured by dispensing a solvent from a needle in an electric field to deposit nanofibers onto a drum rotating at a speed sufficient so as to mechanically stretch and align the nanofibers,
- wherein each of the plurality of piezoelectric films comprises nanofibers substantially aligned with each other,
- wherein the plurality of piezoelectric films is three piezoelectric films arranged as substantially parallel planes with the third piezoelectric film being between the first and second piezoelectric films, and wherein the at least one compressible intervening layer is a first compressible intervening layer between the first piezoelectric film and the third piezoelectric film and a second compressible intervening layer between the second piezoelectric film and the third piezoelectric film, and
- wherein the substantially aligned nanofibers of the first piezoelectric film are substantially parallel with the substantially aligned nanofibers of the second piezoelectric film and are substantially perpendicular with the substantially aligned nanofibers of the third piezoelectric film.
8 more elements
A method of treatment for osteoarthritis comprising:
- identifying a cartilage or bone defect to be treated;
- providing an implantable scaffold comprising a plurality of piezoelectric films and at least one compressible intervening layer between at least two of the plurality of piezoelectric films;
- implanting the implantable scaffold adjacent the cartilage or bone defect to be treated and within a pinch point of a joint;
- and
- providing an exercise protocol for generating periodic impact at the pinch point, such that the periodic impact applies a mechanical force to a first piezoelectric film of the plurality of piezoelectric films such that the first piezoelectric film compresses the compressible intervening layer and deforms towards the second piezoelectric film,
- wherein the cartilage or bone defect to be treated is in a knee joint and wherein the exercise protocol is a walking protocol for generating periodic impact at the knee joint.
3 more elements
A method of treatment for osteoarthritis comprising:
- identifying a cartilage or bone defect to be treated;
- providing an implantable scaffold comprising a plurality of piezoelectric films and at least one compressible intervening layer between at least two of the plurality of piezoelectric films;
- implanting the implantable scaffold adjacent the cartilage or bone defect to be treated and within a pinch point of a joint;
- and
- providing an exercise protocol for generating periodic impact at the pinch point, such that the periodic impact applies a mechanical force to a first piezoelectric film of the plurality of piezoelectric films such that the first piezoelectric film compresses the compressible intervening layer and deforms towards the second piezoelectric film,
- wherein upon identifying the cartilage or bone defect to be treated and prior to providing the implantable scaffold, at least one characteristic of the implantable scaffold is selected based on a characteristic of a patient in which the cartilage or bone defect was identified, and
- wherein at least one of a porosity of nanofibers of the plurality of piezoelectric films, a number of compressible intervening layers, and a thickness of at least one of the compressible intervening layers is selected based on a weight of the patient to tune the implantable scaffold.
4 more elements
Dependencies are inferred from the claim text.