Microneedle integrated 3D printed micropump combined with polymeric nanoparticles for rapid release transdermal drug delivery

A transdermal drug delivery method, comprising:

• (a) having a transdermal drug delivery system comprising:
• (i) a triggering subsystem having a Shape Memory Alloy (SMA) spring attached to and above an iron trigger,
• (ii) a drug delivery subsystem situated below the triggering subsystem, wherein the drug delivery subsystem has a preloaded pumping spring and a damping foam situated above a magnet, and as such the preloaded pumping spring and the damping foam are positioned in between a bottom side of the iron trigger and a top side of the magnet, and a bottom side of the magnet is attached to an elastic membrane lining, and
• (iii) a microneedle subsystem having a pump chamber containing a drug, the elastic membrane lining an inside of the pump chamber, and an array of hollow microneedles at a bottom of the pump chamber;
• and
• (b) controlling a current to the SMA spring resulting in the SMA spring to heat and shrink to an original length of the SMA spring, thereby separating the SMA spring and the attached iron trigger from the magnet resulting in extension of the preloaded pumping spring and the damping foam, wherein the extension of the preloaded pumping spring and the damping foam results in pushing the elastic membrane lining that pushes the drug in the pump chamber through the array of hollow microneedles, which are in contact with a skin portion, pushing the drug via the array of hollow microneedles into the skin portion.