Devices and methods for delivery of pharmaceutical compositions

An intranasal delivery device for treating an opioid overdose comprising:

• a nasal applicator comprising a shaft and an applicator tip coupled to the shaft;
• and
• an absorbent swab material coupled to the applicator tip, wherein,
• the absorbent swab material holds from 50 μL to 450 μL of an aqueous naloxone-containing formulation, wherein,
• the naloxone-containing formulation has:
• a naloxone HCl concentration of from 30 mg/mL to 70 mg/mL;
• and
• a pH from 3.5 to 5.5;
• and
• from 1 mg to 20 mg of naloxone HCl;
• the absorbent swab material is configured to hold the naloxone-containing formulation and to release the naloxone-containing formulation when pressed against the nasal mucosa;
• the nasal applicator is configured to contact the absorbent swab material to the nasal mucosa between from 0.5 cm to 3.0 cm from an opening of the nasal passage;
• and
• the applicator tip does not comprise an injection mechanism.