Radionuclide and near-infrared dye conjugated antibody for detection of GD2-positive cancer

Abstract

Disclosed herein is an antibody-conjugate comprising a monoclonal antibody that specifically binds to GD2 and comprises a heavy chain and a light chain comprising heavy and light chain variable regions set forth as SEQ ID NOs: 3 and 4, respectively. The monoclonal antibody can be conjugated to a near-infrared fluorescent dye and diethylenetriaminepentaacetic acid (DTPA). In several aspects, the antibody-conjugate further comprising Indium-111 (111In) chelated by the DTPA. The antibody-conjugate specifically binds to GD2, and is useful, for example, in radio-guided and fluorescent-guided surgical techniques for intraoperative detection of GD2-positive cancer tissue.

Dependencies are inferred from the claim text.