Long-term stable live fecal microbiota composition

A method for treating dysbiosis in a subject in need thereof, the method comprising:

• administering a solid oral pharmaceutical composition to a subject in need thereof, wherein the solid oral pharmaceutical composition comprises a pharmaceutically effective amount of non-lyophilized living fecal microbiota extract in admixture with one or more pharmaceutically acceptable water absorbing excipients comprising microcrystalline cellulose (MCC), wherein the ratio between the amount of living microorganisms expressed in volume units and the amount of water absorbing excipient(s), expressed in weight units, is from 0.1:1 to 0.99:1, wherein the composition has a water content, determined according to European Pharmacopoeia 9.4, section 2.5.12, from 0.5% to 30% with respect to the total weight of the composition, wherein alpha diversity of the non-lyophilized living microorganisms in the solid oral pharmaceutical composition is not significantly different than the alpha diversity of the non-lyophilized living microorganisms before admixture with the one or more water-absorbing excipients, and wherein the solid oral pharmaceutical composition is stable at 4° C. for 3 months.