Methods of decreasing heparan sulfate expression using EXT1 inhibitors
AssigneeUniversity of South Florida
InventorLianchun Wang
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Abstract
The present disclosure provides for a method of decreasing heparan sulfate expression in a subject in need thereof, the method comprising administering an inhibitor of EXT1 gene expression, wherein the inhibitor comprises a therapeutically effective amount of vitamin D. Further provided herein, is a method of treating cancer in a subject in need thereof, the method comprising administering an inhibitor of EXT1 gene expression, wherein the inhibitor comprises a therapeutically effective amount of vitamin D.
Claims20
A method of decreasing heparan sulfate expression in a subject in need thereof, the method comprising administering an inhibitor of EXT1 gene expression, wherein the inhibitor comprises a therapeutically effective amount of vitamin D, and subsequently decreasing heparan sulfate expression by inhibiting EXT1.
A method of treating cancer by decreasing heparan sulfate expression in a subject in need thereof, the method comprising administering an inhibitor of EXT1 gene expression, wherein the inhibitor comprises a therapeutically effective amount of vitamin D, and subsequently decreasing heparan sulfate expression by inhibiting EXT1.
Dependencies are inferred from the claim text.