US 12,766,154 B2Granted

Ursodeoxycholic acid derivatives for the treatment of polycystic diseases

AssigneesAdministracion General De La Comunidad Autonoma De Euskadi, Universidad de Salamanca, Fundacio Institut D'Investigacio Biomedica De Bellvitge (Idibell), Universidad Del Pais Vasco/Euskal Herriko Unibertsitatea

InventorsJesus Maria Banales Asurmendi, Luis Bujanda Fernandez De Pierola, Alvaro Santos Laso, Fernando Pedro Cossio Mora, Ivan Rivilla De La Cruz, Francisco Javier Caballero Camino, Manel Esteller Badosa, Jose Juan Garcia Marin

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Abstract

Compounds derived from ursodeoxycholic acid of formula (I) and to methods for obtaining same, as well as the use thereof in the treatment of polycystic diseases, particularly autosomal dominant polycystic liver disease, autosomal dominant polycystic kidney disease, or autosomal recessive polycystic kidney disease.

Claims8

Dependent claims

A compound of formula (I′):

wherein:
X is hydrogen or a C6-C10 aryl group;
Y is selected from:
—(CH2)n, wherein n is 1-5;
arylidene or heteroarylidene, wherein the arylidene or heteroarylidene are connect by (1,3)
or (1,4) bonds;
—C(O)—N(H)—CH2 (Ar)—, or
—Ar—C(O)—N(H)—CH2—(Ar)—, wherein Ar is arylidene
and
Z is selected from OH and optionally substituted C6-C10 aryl,
or a pharmaceutically acceptable stereoisomer, salt, or solvate thereof.

8 more elements

Dependencies are inferred from the claim text.

Facts

Application: 18/353,525Filed 17 Jul 2023 · division
Priority: ES ES20173148828 Dec 2017
Published: US 2023/0390308 A17 Dec 2023
Granted: 20 Oct 2026
Term ends: Not estimatedThe source records don’t support an estimate.

Classification3 codes

A61K 31/58
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids: containing heterocyclic rings, e.g. danazol,…
A61K 31/575
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids: substituted in position 17 beta by a chain…
A61K
Medicines and medical preparations

Family

Application16/958,429Parent of this division · filed 28 Dec 2018
PCT/ES2018/070840Parent of this division · filed 28 Dec 2018
US 2023/0390308 A1Pre-grant publication · published 7 Dec 2023
US 11,833,160 B2Parent of this division
US 2021/0137946 A1Published application
US 12,766,154 B2This patent

From the US filing history. Foreign family members aren’t listed.

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