Back to results
US 12,766,131 B2Granted
Compostions and methods for treating prostate cancer
AssigneesThe Regents of the University of Michigan, Oregon Health & Science University
InventorsJoshi Alumkal, Zheng Xia
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to compositions, systems, and methods for treating cancer. In particular, the present disclosure relates to compositions, systems, and methods for characterizing and treating prostate cancer (e.g., castration-resistant prostate cancer).
Claims5
A method for treating prostate cancer, comprising:
- a) assaying a sample from a subject diagnosed with prostate cancer for the level of expression of the genes RING FINGER PROTEIN 43 (RNF43), SMALL NUCLEAR RIBONUCLEOPROTEIN POLYPEPTIDE F (SNRPF), TRAB DOMAIN-CONTAINING PROTEIN 2A (TRABD2A), NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT A12 (NDUFA12), GROWTH ARREST-SPECIFIC 2-LIKE 3 (GAS2L3), RIBOSOMAL PROTEIN S24 (RPS24), DNA REPLICATION HELICASE/NUCLEASE 2 (DNA2), RETINITIS PIGMENTOSA (RP5-857K21.10), POC1 CENTRIOLAR PROTEIN B (POC1B), ADENOSINE KINASE (ADK), ATP SYNTHASE F1, SUBUNIT BETA (ATP5B), EXPORTIN, tRNA (XPOT), SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 1B3 (SLCO1B3), and RHO-RELATED BTB DOMAIN-CONTAINING PROTEIN 1 (RHOBTB1);
- b) calculating a lineage plasticity score based on said level of gene expression;
- c) identifying the subject with a high lineage plasticity score;
- and
- d) administering treatment that does not include an androgen receptor signaling inhibitor treatment to said subject, wherein the treatment includes a prostate cancer treatment that is chemotherapy, radiation, surgery and/or immunotherapy.
2 more elements
A method for treating prostate cancer, comprising:
- a) assaying a sample from a subject diagnosed with prostate cancer for the level of expression of the genes RNF43, SNRPF, TRABD2A, NDUFA12, GAS2L3, RPS24, DNA2, RP5-857K21.10, POC1B, ADK, ATP5B, XPOT, SLCO1B3, and RHOBTB1;
- b) calculating a lineage plasticity score based on said level of gene expression;
- c) identifying the subject with a low lineage plasticity score;
- and
- d) administering an androgen receptor signaling inhibitor treatment to said the subject.
2 more elements
Dependencies are inferred from the claim text.