Compositions for and methods of precision cancer treatment

A method for treating cancer, the method comprising:

• sequencing a biological sample obtained from a subject having metastatic and/or terminal pancreatic cancer;
• and
• if one or more genomic aberrations in a combination of cancer related genes in the biological sample are identified, then administering to the subject a therapeutically effective amount of A10 and AS2-1,
• wherein A10 comprises phenylacetylglutaminate sodium (PG) and phenylacetylisoglutaminate sodium (iso-PG) in a 4:1 ratio;
• wherein AS2-1 comprises phenylacetate (PN) and PG in a 4:1 ratio;
• wherein the combination of cancer related genes comprises ARID1A, KIT, KRAS, NF1, SMAD4, and TP53;
• and
• measuring the subject's tumor response and/or molecular response to the A10 and AS2-1,
• wherein treating the cancer comprises increasing the subject's survivability, increasing the length of time before metastasis, reducing the likelihood of surgical intervention, reducing the need for administration of one or more additional therapeutic agents or regiments, reducing the size of one or more tumors in the subject, eliminating one or more tumors in the subject, reducing or eliminating the prevalence of one or more genomic aberrations, restoring the normal metabolism of one or more organ systems in the subject, restoring one or more aspect of cellular homeostasis and/or cellular functionality and/or metabolic dysregulation, or any combination thereof.