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US 12,766,100 B2Granted
In vivo targeting of extracellular vesicles
AssigneeMayo Foundation for Medical Education and Research
InventorsAditya Bansal, Timothy R. DeGrado, Mukesh K. Pandey
Life of this patent
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Abstract
A method for chemically induced homing of extracellular vesicles (EVs) to a specific tissue or organ in a subject for either treatment or diagnosis of a medical condition, the method comprising administering to the subject an amount of a homing agent. The homing agent is at least one of a derivative of poly(ethylene glycol), or a derivative of phenothiazine. The EVs are homed to the homing agent in the subject.
Claims29
A method for treating a medical condition in a subject, the method comprising:
- (a) administering to the subject a homing agent at an administration site, wherein the homing agent is poly(ethylene glycol);
- and
- (b) administering to the subject a structure comprising a bioactive agent thereby associating naturally occurring extracellular vesicles already present within the subject with the bioactive agent and waiting a time sufficient such that the naturally occurring extracellular vesicles within the subject are homed to the homing agent in the subject,
- wherein the administration site is at least one of a tissue, a blood vessel, or a lymph vessel.
1 more element
A method for treating a medical condition in a subject, the method comprising:
- (a) administering to the subject an amount of homing agent at an administration site, wherein the homing agent is poly(ethylene glycol);
- (b) administering to the subject extracellular vesicles, each of the extracellular vesicles being associated with a bioactive agent;
- and
- (c) waiting a time sufficient such that the administered extracellular vesicles are homed to the homing agent in the subject.
1 more element
A method for treating a medical condition in a subject, the method comprising:
- (a) administering to the subject an amount of a homing agent, wherein the homing agent is a derivative of poly(ethylene glycol), and wherein at least one atom in the derivative of poly(ethylene glycol) is associated with a biological targeting agent defining a targeted homing agent, the biological targeting agent allowing targeting of the homing agent to a specific location within the subject;
- (b) waiting a time sufficient to allow the targeted homing agent to accumulate at the specific location within the subject, due to the biological targeting agent associated with the homing agent;
- and
- (c) administering to the subject a structure comprising a bioactive agent and optionally administering extracellular vesicles to the subject;
- thereby associating naturally occurring extracellular vesicles already present within the subject with the bioactive agent and waiting a time sufficient such that the naturally occurring extracellular vesicles (EVs) within the subject, and/or administered EVs accumulate at the specific location of the subject, due to the homing of the extracellular vesicles to the homing agent of the targeted homing agent.
2 more elements
A method for treating a medical condition in a subject, the method comprising:
- (a) administering to the subject a homing agent, wherein the homing agent is a derivative of poly(ethylene glycol), and wherein at least one atom in the derivative of poly(ethylene glycol) is associated with a biological targeting agent defining a targeted homing agent, the biological targeting agent allowing targeting of the homing agent to a specific location within the subject;
- (b) waiting a time sufficient to allow the targeted homing agent to accumulate at the specific location within the subject, due to the biological targeting agent associated with the homing;
- and
- (c) administering to the subject a structure comprising a bioactive agent thereby associating naturally occurring extracellular vesicles already present within the subject with the bioactive agent and waiting a time sufficient such that the naturally occurring extracellular vesicles within the subject accumulate at the specific location of the subject, due to the homing of the extracellular vesicles to the targeted homing agent.
1 more element
A method for treating a medical condition in a subject, the method comprising:
- (a) administering to the subject a homing agent, wherein the homing agent is a derivative of poly(ethylene glycol), and wherein at least one atom in the derivative of poly(ethylene glycol) is associated with an associated biological targeting agent defining a targeted homing agent, the biological targeting agent allowing targeting of the homing agent to a specific location within the subject;
- (b) associating extracellular vesicles with a bioactive agent and administering to the subject the extracellular vesicles;
- (c) waiting a time sufficient to allow the targeted homing agent to accumulate at the specific location within the subject, due to the biological targeting agent associated with the homing agent;
- (d) waiting a time sufficient such that the administered extracellular vesicles home to the specific location within the subject, due to the homing of the extracellular vesicles to the homing agent of the targeted homing agent.
1 more element
Dependencies are inferred from the claim text.