Lumen apposing stent to deliver targeted therapy

A system, comprising:

• a stent comprising a lumen extending longitudinally therethrough, the stent configured to shift between a first configuration and a second configuration;
• a functional and/or therapeutic agent delivered by the system in a gel or liquid form or in a gel or liquid carrier through a space surrounding yet not in communication with the stent when the stent is in the first configuration to be extruded over the stent when the stent is extended into the second configuration;
• and
• a cap provided along a distal end of the space surrounding the stent and removable to allow release of the functional and/or therapeutic agent;
• wherein:
• in the second configuration, the stent defines a first retention member, a second retention member, and a saddle region extending therebetween;
• and
• when the stent is positioned within a body lumen in the second configuration, the first retention member, the second retention member, the saddle region, and the tissue wall of the lumen define a volume configured to retain the functional and/or therapeutic agent when extruded therein and over at least the saddle region.

A method for creating an anastomosis, including:

• advancing a delivery system from a first lumen across first and second tissues and into a second lumen, wherein the delivery system comprises:
• a first sheath;
• an inner member;
• a stent disposed within the first sheath and about the inner member, the stent configured to transition between a first configuration and a second configuration;
• a second sheath disposed about the first sheath;
• a functional and/or therapeutic agent in gel or liquid form, the functional and/or therapeutic agent disposed in a space defined between the first sheath and the second sheath;
• and
• a cap provided along a distal end of the first sheath and/or a distal end of the second sheath and removable to allow release of the functional and/or therapeutic agent;
• removing the cap;
• proximally retracting the first and second sheath with respect to the inner member, distally extending the inner member with respect to the first sheath and second sheath, or both such that:
• a first end of the stent is extended distally outside the first sheath and forms the first retention member within the second body lumen;
• and
• the functional and/or therapeutic agent is disposed on a surface of the stent;
• and
• proximally retracting the first sheath with respect to the inner member, distally extending the inner member with respect to the first sheath, or both such that a second end of the stent is unconstrained from the first sheath and forms the second retention member within the first body lumen.