Systems and methods for classifying and amelioration of adverse side effects associated with sub-cutaneous regions exhibiting impedance that is different than that of adjecent tissue

A system for use in a procedure for ameliorating adverse side effects associated with a sub-cutaneous region exhibiting impedance that is different than the surrounding tissue and/or organ in a subject in need thereof, by applying RF energy thereto, the device comprising:

• a) a wand having a at least one needle adapted, sized and configured to penetrate a surface of a skin region of the subject;
• b) a radio frequency (RF) generator, arranged to deliver RF energy to the sub-cutaneous region exhibiting impedance that is different than the surrounding tissue and/or organ via the at least one needle;
• and
• c) a central processing module (CPM), in communication with the wand, and the RF generator, the CPM further comprises at least one processor in communication with a non-transitory memory device, storing thereon a computer-readable media with a set of executable instructions configured, when executed by the at least one processor to:
• i. control depth of penetration of the at least one needle;
• ii. control an intensity of an RF energy delivery by the RF generator to the sub-cutaneous region exhibiting impedance that is different than the surrounding tissue and/or organ;
• iii. selectably control penetration depth of each needle in an array of the plurality of needles;
• iv. detect electrical impedance measured in each needle in the array of the plurality of needles penetrated to the area beneath the penetrated skin;
• and
• v. dynamically assign polarity to each needle of the plurality of needles penetrated to the area beneath the penetrated skin, based on the detected impedance, wherein the sub-cutaneous region exhibiting impedance that is different than the surrounding tissue and/or organ, is a focal tunical fibrosis, exhibiting a higher impedance.