Tissue ablation apparatus, and electrochemical impedance measurement apparatus and method

A tissue ablation apparatus, comprising:

• a high-voltage pulse module configured to generate a high-voltage pulse signal according to a pulse control signal, and apply the high-voltage pulse signal to a target tissue through a first output end and a second output end of the high-voltage pulse module wherein the first output end is configured to connect to a first electrode and the second output end is configured to connect to a second electrode;
• a Faraday current detection module arranged between the high-voltage pulse module and the first electrode and the second electrode and configured to generate a sampling signal based on a current flowing through the first electrode and a current flowing through the second electrode;
• a differential sampling module connected to the first output end and the second output end of the high-voltage pulse module and configured to generate and output a first feedback voltage and a second feedback voltage according to a voltage change of the first output end and a voltage change of the second output end respectively;
• a voltage processing module connected to the differential sampling module and configured to generate and output a voltage feedback signal according to the first feedback voltage and the second feedback voltage, wherein the voltage feedback signal corresponds to a voltage difference between the first output end and the second output end;
• a high-frequency sampling module, connected to the voltage processing module and the Faraday current detection module, and configured to generate and output a digital feedback signal according to the voltage feedback signal and the sampling signal;
• and
• a main control module connected to the high-voltage pulse module and the high-frequency sampling module and configured to obtain a Faraday current and the voltage difference between the first output end and the second output end according to the received digital feedback signal, obtain an electrochemical impedance parameter of the target tissue by the Faraday current, the voltage difference between the first output end and the second output end and an electrochemical impedance fitting function, and generate the pulse control signal according to the electrochemical impedance parameter, wherein the electrochemical impedance fitting function is obtained by fitting electrical parameters obtained in a pulsed electric field ablation simulation experiment performed based on an equivalent circuit model of the target tissue.