Integrated sampling and analysis device
AssigneemiDiagnostics NV
InventorDavid Mikaelian
Life of this patent
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Abstract
The field of the invention generally relates to sample collection, for example of a sample being an exhaled breath. In particular, an integrated device is disclosed herein comprising a silicon chip for sampling particulate matter from a sample and for analysis, preferably by a protocol using thermocycling, of the particulate matter as collected from the sample. Further, point-of-care (PoC) and self-use analysis systems compatible with the integrated device, and methods related to sample collection and/or analysis using the same, are also disclosed.
Claims28
A collecting device for sampling particulate matter from a sample, the collecting device comprising:
- a base structure;
- a monolithic silicon chip supported by said base structure, the chip comprising at least two opposite sides and a top surface and an opposite thereto bottom surface, wherein the bottom surface is closed allowing contacting with a heating source and wherein the top surface comprises a plurality of patterned impaction channels for capturing particulate matter present in the sample, and extending between the at least two opposite sides of the chip, each one of the impaction channels comprising at least one impaction channel inlet and at least one impaction channel outlet and comprising one or more T-junctions between the at least one impaction channel inlet and the at least one impaction channel outlet;
- a cover in contact with the base structure and comprising a chip-contacting layer that is in contact with the chip's top surface and is at least partially covering the impaction channels,
- wherein the cover is configured to define at least one sample inlet opening and at least one sample outlet opening, and further together with the chip's top surface to define an at least one sample inlet channel that is in fluidic connection with the at least one impaction channel inlet and that is arranged for guiding at least a part of the sample into the one or more T-junctions, and an at least one sample outlet channel that is in fluidic connection with the at least one impaction channel outlet and that is positioned downstream of the one or more T-junctions,
- wherein the cover is arranged such that fluidic connection between the at least one sample inlet channel and the at least one sample outlet channel is established by the one or more T-junctions;
- and
- a transparent zone that covers an area of the top surface of the chip, which area comprises the one or more of T-junctions for presenting said area to light-based detection of an analyte possibly captured in said one or more of T-junctions.
Dependencies are inferred from the claim text.