US 12,760,193 B2 · Methacrylated nanoparticles and related method

Abstract

A photocrosslinkable agent includes at least one methacrylate-modified nanoparticle that includes a plurality of molecules attached to surface of a nanoparticle. At least a portion of the molecules includes a molecule that includes a nanoparticle surface attachment ligand a terminal methacrylate ligand. At least a portion of the molecules may include a second molecule that includes a nanoparticle surface attachment ligand and a hydrophilic terminal ligand, wherein the methacrylate-modified nanoparticle has water solubility that is controlled by the relative amounts of the terminal methacrylate ligand and the hydrophilic terminal ligand. The photocrosslinkable agent may be crosslinked within a polymer network by a one-step process, with minimal disruption to the molecular network or crosslinking density and may be formulated for use as one or more of an imaging contrast agent, a therapeutic, or a reinforcement, a transducer.

Claims20

Dependent claims

A photocrosslinkable agent comprising:

a. at least one water-soluble methacrylate-modified nanoparticle (100) comprising:
i. a nanoparticle;
and
ii. a plurality of molecules attached to a surface of the nanoparticle, each of the plurality of molecules comprising a nanoparticle surface attachment ligand (1), a first portion of the plurality of molecules including a terminal methacrylate ligand (103), and a second portion of the plurality of molecules including a hydrophilic terminal ligand (2),
wherein any one of the plurality of molecules may include more than one nanoparticle surface attachment ligand and more than one terminal ligand.

2 more elements

A photocrosslinkable ink for forming a material or structure, comprising:

a. a suitable solvent comprising water;
b. a plurality of water-soluble methacrylate-modified nanoparticles, each of the methacrylate-modified nanoparticles comprising:
i. a nanoparticle;
and
ii. a plurality of molecules attached to a surface of the nanoparticle, each of the plurality of molecules comprising a nanoparticle surface attachment ligand (1) and at least a portion of the plurality of molecules comprising a terminal methacrylate ligand (103);
and at least a portion of the molecules comprising a hydrophilic terminal ligand (2), wherein any one of the plurality of molecules may include more than one nanoparticle surface attachment ligand and more than one terminal ligand,
c. optionally, a plurality of methacrylate-modified macromolecules (107);
and
d. a photoinitiator.

6 more elements

A method for providing a photocrosslinkable agent, the method comprising:

a. providing a nanoparticle;
b. providing a first bifunctional molecule (105) comprising a nanoparticle surface attachment ligand (1) that is attached to a surface of the nanoparticle, and a terminal ligand comprising a hydrophilic terminal ligand (2) capable of covalent linking to a terminal ligand of another molecule;
c. providing a second bifunctional molecule (106) comprising a terminal methacrylate ligand (103) and a terminal ligand comprising a coupling ligand (4) capable of covalent linking to the hydrophilic terminal ligand (2) of the first molecule;
and
d. covalently linking the hydrophilic terminal ligand (2) of the first molecule to the coupling ligand (4) of the second molecule, optionally in the presence of a coupling agent or catalyst, forming a water-soluble methacrylate-modified nanoparticle,
wherein any one of the first, second or both first and second bifunctional molecules may include more than one nanoparticle surface attachment ligand and more than one terminal ligand.

3 more elements

Dependencies are inferred from the claim text.

Methacrylated nanoparticles and related method

Life of this patent

Methacrylated nanoparticles and related method

Life of this patent

Abstract

Claims20