Bispecific antibodies binding HVEM and CD9

An antibody which comprises a first antigen-binding portion binding HVEM and a second antigen-binding portion binding CD9, wherein the first antigen-binding portion binding HVEM comprises a first heavy chain variable region and a first light chain variable region, wherein the second antigen-binding portion binding CD9 comprises a second heavy chain variable region and a second light chain variable region, and wherein:

• a. the first heavy chain variable region comprises a CDR-H1 comprising SEQ ID NO:
• 3, a CDR-H2 comprising SEQ ID NO:
• 4 and a CDR-H3 comprising SEQ ID NO:
• 5;
• and
• b. the first light chain variable region comprises a CDR-L1 comprising SEQ ID NO:
• 6, a CDR-L2 comprising SEQ ID NO:
• 7 and a CDR-L3 comprising SEQ ID NO:
• 8;
• and
• c. the second heavy chain variable region comprises a CDR-H1 comprising SEQ ID NO:
• 9, a CDR-H2 comprising SEQ ID NO:
• 10 and a CDR-H3 comprising SEQ ID NO:
• 11;
• and
• d. the second light chain variable region comprises a CDR-L1 comprising SEQ ID NO:
• 12, a CDR-L2 comprising SEQ ID NO:
• 13 and a CDR-L3 comprising SEQ ID NO:
• 14.