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US 12,760,091 B2Granted
Fibronectin targeting chimeric antigen receptors (CARs)
AssigneeThe Trustees of the University of Pennsylvania
InventorsAvery D. Posey, Jr., Tiffany King
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Abstract
The present disclosure provides compositions and methods comprising chimeric antigen receptors (CARs) capable of binding tumor-specific isoforms of fibronectin.
Claims16
A chimeric antigen receptor (CAR) comprising an antigen binding domain capable of binding the IIICS domain of fibronectin, a transmembrane domain, and an intracellular domain, wherein the antigen binding domain comprises:
- i. at least one heavy chain variable region (HCDR) comprising the nucleotide sequence selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO:
- 2, and SEQ ID NO:
- 3;
- and
- ii. at least one light chain variable region (LCDR) comprising the nucleotide sequence selected from the group consisting of SEQ ID NO:
- 4, SEQ ID NO:
- 5, and SEQ ID NO:
- 6.
6 more elements
Dependencies are inferred from the claim text.