Back to results
US 12,760,070 B2Granted
Cyclic cell penetrating peptides and methods of making and using thereof
AssigneeOhio State Innovation Foundation
InventorsDehua Pei, Ziqing Qian
Life of this patent
Estimating the term…
Abstract
Disclosed herein are peptides having activity as cell penetrating peptides. In some embodiments, the peptides can comprise a cell penetrating peptide moiety and beta-haripin turn creating moiety. In other embodiments, the peptides also comprise a cargo moiety.
Claims10
A compound comprising;
- i. a cyclic cell penetrating 8 amino acid peptide, wherein the amino acids are connected through peptide bonds, that contains;
- a. one arginine within two amino acids of another arginine;
- b. a phenylalanine within two amino acids of another phenylalanine;
- and
- ii. an exocyclic cargo moiety conjugated to a side chain of the cell penetrating peptide wherein the conjugation is through glutamine and wherein the cargo comprises an amino acid sequence that targets an enzyme.
2 more elements
Dependencies are inferred from the claim text.