Optimized peptides for targeting human nerves and their use in image guided surgery, diagnostics and therapeutic delivery
AssigneeThe Regents of the University of California
InventorsQuyen T. Nguyen, Mike Whitney, Dina Hingorani, Roger Y. Tsien, Stephen Adams
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Abstract
The present invention provides methods for guiding preservation of human neurons or human nerves during surgery by administering a fluorescently-labeled peptide that specifically binds to the human neurons or human nerves. The invention further provides human neuron or nerve targeting molecules comprising fluorescently-labeled peptides that specifically bind to human neurons or human nerves and compositions thereof.
Claims25
A targeting molecule comprising a peptide having the sequence set forth in SGQVPWEEPYYVVKKSS (HNP-401, SEQ ID NO:1) or a variant thereof having 2-8 amino acids deleted from the N-terminus or C-terminus, wherein the peptide is conjugated to a drug.
Dependencies are inferred from the claim text.