Glucocorticoid receptor modulators

A compound or pharmaceutically acceptable salt thereof, wherein the compound has a structure corresponding to Formula (IV-A1):

• wherein Cy is an optionally substituted mono- or poly-cyclic moiety selected from the group consisting of C6-15-aryl, 5-to 15-membered heteroaryl, C3-15-cycloalkyl, C3-15-cycloalkenyl, 3-to 15-membered heterocycloalkyl, and 3- to 15-membered heterocycloalkenyl;
• X is absent or selected from the group consisting of —NRZ—, —C(RZ)2—, —O—, —C(O)—, and —S(O)y—, wherein each RZ is independently hydrogen, C1-6-alkyl, C1-6-haloalkyl, C2-6-alkenyl, C2-6-haloalkenyl, C2-6-alkynyl, C2-6-haloalkynyl, or C3-8-cycloalkyl, and y is 0, 1, or 2;
• R9 is C1-10-alkyl or C1-10-haloalkyl, each of which is optionally interrupted by one or more of —O—, —NRZ—, —C(O)—, —C(O)O—, —OC(O)—, —C(O)NRZ—, and —NRZC(O)—;
• or
• R9 is
• wherein Q is absent or selected from the group consisting of C1-C10-alkylene, C1-C10-haloalkylene, C2-C10-alkenylene, C2-C10-haloalkenylene, C2-C10-alkynylene, C2-C10-haloalkynylene, each of which is optionally interrupted by one or more of —O—, —NRZ—, —C(O)—, —C(O)O—, —OC(O)—, —C(O)NRZ—, —NRZC(O)—, —S(O)y—, —S(O)yNRZ—, —NRZS(O)y—, —C(S)NRZ—, —NRZC(S)—;
• and
• E is selected from the group consisting of C6-10-aryl, 5- to 10-membered heteroaryl, C3-8-cycloalkyl, or 3- to 8-heterocycloalkyl;
• R13 is selected from the group consisting of C1-10-alkyl, C1-10-haloalkyl, C2-10-alkenyl, C2-10-haloalkenyl, C2-10-alkynyl, C2-10-haloalkynyl, each of which is optionally interrupted by one or more of —O—, —NRZ—, —C(O)—, —C(O)O—, —OC(O)—, —C(O)NRZ—, —NRZC(O)—, —S(O)y—, —S(O)yNRZ—, —NRZS(O)y, —C(S)NRZ—, and —NRZC(S)—;
• RD is selected from the group consisting of hydrogen C1-10-alkyl, C1-10-haloalkyl, C2-10-alkenyl, C2-10-haloalkenyl, C2-10-alkynl, C2-10-haloalkynyl, —(CH2)m- C6-10-aryl, —(CH2)m-5- to 10-membered heteroaryl;
• m is an integer selected from the group consisting of 0, 1, 2, and 3;
• wherein any C6-10-aryl, 5- to 10-membered heteroaryl, C3-8-cycloalkyl, or 3- to 8-heterocycloalkyl is optionally substituted with one or more halogen, hydroxy, C1-6-alkyl, C1-6-haloalkyl, or C1-6-alkoxy.