SIK inhibitors

A compound of formula IA having the structure:

• or a pharmaceutically acceptable salt thereof, wherein
• A1 and A2 are independently O or S;
• X is selected from CH2, CD2, NR3, O, and S, where R3 is selected from hydrogen, C1-C4 linear or branched chain alkyl, halo(C1-C4) linear or branched chain alkyl, and hydroxyl(C1-C4) linear or branched chain alkyl;
• R1 and R2 are independently selected from hydrogen, deuterium, C1-C4 linear or branched chain alkyl, halo(C1-C4) linear or branched chain alkyl, hydroxyl(C1-C4) linear or branched chain alkyl, cyano (C1-C4) linear or branched chain alkyl, and C1-C3 alkoxy (C1-C4) linear or branched chain alkyl;
• or a C1-C2 alkyl substituted with a C3-C5 cycloalkyl ring;
• or taken together to form a C3-C6 cycloalkyl ring;
• or where X is CH2 or CD2, then R1 and R2 are independently selected from hydrogen, deuterium, halogen, hydroxyl, C1-C4 linear or branched chain alkyl, halo(C1-C4) linear or branched chain alkyl, hydroxyl(C1-C4) linear or branched chain alkyl, cyano (C1-C4) linear or branched chain alkyl, and C1-C3 alkoxy (C1-C4) linear or branched chain alkyl, and a C1-C2 alkyl substituted with a C3-C5 cycloalkyl ring;
• R4 is selected from hydrogen, deuterium, cyano, halogen, (C1-C3) alkoxy, halo(C1-C3) alkoxy, C1-C3 alkyl-substituted thiol, C1-C4 linear or branched chain alkyl, halo(C1-C4) linear or branched chain alkyl, and a hydroxyl(C1-C4) linear or branched chain alkyl;
• R5 is selected from hydrogen, deuterium, halogen, C1-C3 alkoxy, amino, (C1-C4 linear or branched chain alkyl)amino, di(C1-C4 linear or branched chain alkyl)amino, (4-6 membered) heterocyclic, C1-C4 linear or branched chain alkyl, halo(C1-C4) linear or branched chain alkyl, and a hydroxyl(C1-C4) linear or branched chain alkyl;
• R6 is selected from hydrogen, deuterium, halogen, C1-C4 linear or branched chain alkoxy, CONH2, C1-C4 linear or branched chain alkyl, halo(C1-C4) linear or branched chain alkyl, hydroxyl(C1-C4) linear or branched chain alkyl, and CO2R7 where R7 is selected from H and C1-C4 linear or branched chain alkyl;
• R8 is selected from hydrogen, deuterium, and C1-C3 linear or branched chain alkyl;
• R9 is selected from C1-C3 linear or branched chain alkyl, and a halo(C1-C3) linear or branched chain alkyl;
• and,
• n and m are independently selected from 0, 1 and 2.