Heteroaryl derivative, method for preparation thereof, and pharmaceutical composition comprising same as active ingredient

A compound of Formula 1, or a pharmaceutically acceptable salt thereof:

• wherein:
• E1 is N;
• R1 is hydrogen, C1-5 alkoxy, or alkoxy substituted by halogen;
• X1 is CH, N, O or S;
• wherein when X1 is CH,
• R2 and R3 form, together with a bonded C, a 3 to 12 atom heteroaryl comprising at least one N, and the 3 to 12 atom heteroaryl is substituted or unsubstituted by a C1-5 straight chain or branched chain alkyl or a 3 to 12 atom heterocycloalkyl,
• wherein when X1 is N,
• R2 and R3 are each independently selected from the group consisting of:
• hydrogen and C1-5 straight chain or branched chain alkyl, or
• R2 and R3 form, together with a bonded N, a 3 to 12 atom heterocycloalkyl, wherein the 3 to 12 atom heterocycloalkyl comprises one or more heteroatoms, and wherein each heteroatom of the one or more heteroatoms is selected from the group consisting of:
• N, O and S, wherein the C1-5 straight chain or branched chain alkyl is substituted or unsubstituted by a C1-5 alkylamino, wherein the 3 to 12 atom heterocycloalkyl comprises one or more heteroatoms, each heteroatom of the one or more heteroatoms being selected from the group consisting of:
• N, O and S, is substituted or unsubstituted by one or more substituents A,
• wherein each substituent A of the one or more substituents A is selected from the group consisting of:
• C1-5 straight chain or branched chain alkyl, C3-6 cycloalkyl, C1-5 alkylamino, allyl, oxo, C1-3 alkylcarbonyl, and 3 to 12 atom heterocycloalkyl, wherein the 3 to 12 atom heterocycloalkyl comprises one or more heteroatoms, wherein each heteroatom of the one or more heteroatoms is selected from the group consisting of:
• N and O, wherein the C1-5 straight chain or branched chain alkyl is additionally substituted or unsubstituted by a C3-6 cycloalkyl, a C1-5 alkylamino, or a 3 to 12 atom heterocycloalkyl that comprises at least one N, wherein the 3 to 12 atom heterocycloalkyl is substituted or unsubstituted by a substituent B,
• wherein the substituent B is selected from the group consisting of:
• C1-5 straight chain or branched chain alkyl, C3-6 cycloalkyl, C1-5 alkylcarbonyl, a 3 to 12 atom heterocycloalkyl that includes one or more heteroatoms, and oxo, and wherein each heteroatom of the one or more heteroatoms is selected from the group consisting of:
• N and O, wherein the 3 to 12 atom heterocycloalkyl is additionally substituted or unsubstituted by a C1-5 straight chain or branched chain alkyl or a C3-6 cycloalkyl;
• wherein when X1 is S or O,
• R2 does not exist and R3 is C1-5 alkyl substituted by C1-5 alkylamino;
• and R4 and R5 are each independently selected from the group consisting of:
• hydrogen, halogen, and haloalkyl, or R4 and R5 form, together with a benzene, a 7 to 12 atom heteroaryl that includes one or more heteroatoms, wherein each heteroatom of the one or more heteroatoms is selected from the group consisting of:
• N, O and S, and wherein the 7 to 12 atom heteroaryl is substituted or unsubstituted by a C1-5 straight chain or branched chain alkyl.