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US 12,760,010 B2Granted
5-hydroxy-1,4-naphthalenedione for use in the treatment of cancer
AssigneeGodavari Biorefineries Limited
InventorsSandip Gavade, Sangeeta Srivastava, Prashant Kharkar, Maithili Athavale
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Abstract
The present invention discloses compounds for inhibition of uncontrolled cell proliferation particularly cancer stem cells. Particularly, the invention relates to compounds of Formula (I) to (IV) for the treatment of cancer.
Claims10
A compound of Formula I:
- wherein,
- n is 1-6;
- Q is O or -Q-(CH2)n-R is absent;
- R1, R2, and R3 are each —H;
- R4 is selected from —H,
- R is selected from —COOH,
- R6 is selected from —H,
- represents point of attachment,
- when R=—COOH, n=3 to 6 and R6 is selected from
- wherein the compound is selected from any one of the following compounds:
7 more elements
A pharmaceutical composition comprising a compound of Formula I:
- wherein,
- n is 1-6;
- Q is O or -Q-(CH2)n-R is absent;
- R1, R2, and R3 are each —H;
- R4 is selected from —H,
- R is selected from —COOH,
- R6 is selected from —H,
- * represents point of attachment,
- when R=—COOH, n=3 to 6 and R6 is selected from
- and at least one pharmaceutically acceptable excipient in the presence or absence of one or more active agent.
7 more elements
A pharmaceutical composition for use in treatment of unregulated cell growth or cancer comprising a compound of Formula I:
- wherein,
- n is 1-6;
- Q is O or -Q-(CH2)n-R is absent;
- R1, R2, and R3 are each —H;
- R4 is selected from —H,
- R is selected from —COOH,
- R6 is selected from —H,
- * represents point of attachment,
- when R=—COOH, n=3 to 6 and R6 is selected from
6 more elements
Dependencies are inferred from the claim text.