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US 12,759,987 B2Granted
Cardiac therapeutic
AssigneeNational University of Singapore
InventorsChun Yong Eric Chan, Aneesh Vidyadhar Karkhanis, Gopalakrishnan Venkatesan
Life of this patent
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Abstract
The invention concerns a novel cardiac therapeutic effective against atrial fibrillation (AF); a pharmaceutical composition comprising same; the use of same to treat cardiac disease; and a method of treating cardiac disease involving the use of same.
Claims12
A compound according to Formula (I) or a pharmaceutically acceptable salt thereof:
- wherein:
- R1, R2 and R3 each represents deuterium;
- n represents 2 or 3;
- each R4 independently represents a C1-6 hydrocarbyl group which may be substituted with one or more of nitro, halogen, amino, amido, cyano, carboxyl, sulphonyl, hydroxyl, ketone or aldehyde groups;
- R5 represents hydrogen or
- and
- each R6 independently represents hydrogen or halogen.
4 more elements
A compound according to Formula (III) or a pharmaceutically acceptable salt thereof:
- wherein each R7 represents deuterium.
Dependencies are inferred from the claim text.