Back to results
US 12,758,688 B2Granted
Medical devices including therapeutic coatings for local delivery of a direct anticoagulant
AssigneeBoston Scientific Scimed, Inc.
InventorsThomas John Herbst, Edward Kopesky, Steven L. Kangas, Hongxia Zeng, Aaron Cooper Foss
Life of this patent
Estimating the term…
Abstract
A medical device may be coated with a therapeutic composition that includes a direct oral anticoagulant. An illustrative drug coating composition may comprise an excipient including polylactic acid (PLA), poly(lactic-co-glycolic acid) (PLGA), or poly(vinylidene fluoride)-co-hexafluoropropylene (PVDF-HFP) and a direct oral anticoagulant (DOAC). The illustrative drug coating may be applied to an outer surface of a medical device.
Claims6
A method for manufacturing a drug coating composition, the method comprising:
- dissolving polylactic acid (PLA) or poly(lactic-co-glycolic acid) (PLGA) and rivaroxaban in a mixture of dichloromethane and dimethylformamide to form a first solution;
- adding the first solution to aqueous poly (vinyl acid) PVA while mixing to form a bead solution;
- filtering the bead solution to collect a plurality of microspheres;
- and
- drying the plurality of microspheres.
2 more elements
Dependencies are inferred from the claim text.