Micronized placental tissue compositions and methods of making and using the same

A method of preparing micronized human placental tissue particles, said method comprising the steps of:

• i) providing a human amniotic sac collected during a Cesarean section birth, said amniotic sac comprising an amnion and a chorion;
• ii) removing clotted blood from said amnion and chorion;
• iii) chemically decontaminating said amnion and chorion using an antibiotic solution, thereby forming amnion and chorion comprising an antibiotic;
• iv) removing said antibiotic from said amnion and chorion comprising an antibiotic formed in step iii);
• v) dehydrating said amnion and chorion formed in step iv);
• vi) micronizing said dehydrated amnion and chorion, thereby forming micronized human placental tissue particles;
• and
• vii) separating a portion of the micronized human placental tissue particles by size,
• wherein the micronized human placental tissue particles obtained in step vii) have a particle size that is either between 20 and 100 μm or between 150 and 350 μm.