Antibiotics
AssigneeAston University
InventorsJonathan Cox, Nicolas Barry, James Harrison, Victoria Nolan, Anaïs Pitto-Barry, Joan Soldevila-Barreda
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AssigneeAston University
InventorsJonathan Cox, Nicolas Barry, James Harrison, Victoria Nolan, Anaïs Pitto-Barry, Joan Soldevila-Barreda
Estimating the term…
The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt; wherein L is a substituted or non-substituted aromatic ligand; Z is a halogen or coordinating ligand; M is a group 8 or group 9 transition metal selected from; Fe, Ru, Os, Co, Rh and Os; A and B are independently selected from a substituted or non-substituted indole or pyridine, may be the same or different and coordinate to the transition metal M through the nitrogen atom of the indole or pyridine. The compounds have been shown to have use against antibiotic-resistant bacteria. A further aspect of the invention is directed towards treating or preventing bacterial infections.
A method of treating or prophylaxis of a bacterial infection caused by a bacterium comprising administering to a subject an effective amount of a compound or pharmaceutically acceptable salt of a compound of Formula I:
A compound of Formula I
Dependencies are inferred from the claim text.