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US 12,758,561 B2Granted
Administration of benzodiazepine compositions
AssigneeNeurelis, Inc.
InventorsSteve Cartt, David Medeiros, Garry Thomas Gwozdz, Andrew Loxley, Mark Mitchnick, David F. Hale, Edward T. Maggio
Life of this patent
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Abstract
The invention relates to pharmaceutical compositions comprising one or more benzodiazepine drugs for nasal administration, methods for producing and for using such compositions.
Claims27
A pharmaceutical composition for intranasal administration comprising:
- a therapeutically effective amount of a benzodiazepine drug dissolved in about 30% to about 95% (w/w) of one or more natural or synthetic tocopherols or tocotrienols selected from the group consisting of α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocophersolan, any isomers thereof, any esters thereof and any combinations thereof, and about 10% to about 70% (w/w) of one or more alcohols or glycols, or any combinations thereof, and about 0.01% to about 1% (w/v) of an alkyl glycoside, wherein the pharmaceutical composition is a solution and contains less than 1% water, wherein the pharmaceutical composition is in a pharmaceutically-acceptable spray formulation.
Dependencies are inferred from the claim text.