US 12,758,483 B2 · Antibacterial and mineralizing compositions and methods of use thereof

Abstract

Peptides that bind with high affinity to oral cavity surfaces, such as tooth enamel, have been discovered. The peptides exhibit antibacterial and mineralizing abilities, and are useful in many aspects of oral care. A preferred peptide includes the amino acid sequence AKRHHGYKRKFH-SpSp. The peptides can be included in oral care compositions such as toothpastes and mouthwashes. The oral care compositions can be used in methods to treat or prevent diseases or conditions induced by acidophilic oral bacteria. Exemplary methods include reducing or preventing tooth decay or demineralization, biofilm or dental plaque formation, and/or bacterial adhesion to a tooth surface; and promoting mineralization of teeth surfaces.

Claims16

Dependent claims

An isolated peptide comprising an antimicrobial domain and a phosphoserine domain, wherein the antimicrobial domain comprises a histatin 5 segment,

wherein the histatin 5 segment comprises a histatin 5 protein, a variant thereof, a portion thereof, or a variant of a portion thereof,
wherein the phosphoserine domain comprises a phosphorylated serine,
wherein upon contact with a tooth, the isolated peptide binds to the tooth enamel, reduces or prevents tooth decay, reduces or prevents bacterial biofilm formation on the tooth surface, reduces or prevents dental plaque formation, reduces or prevents bacterial adhesion to the tooth surface, induces or increases mineralization, or combinations thereof,
and
(a) wherein the phosphoserine domain comprises two or more phosphorylated serines, or
(b) wherein the phosphoserine domain is at the C-terminus of the isolated peptide.

3 more elements

Dependencies are inferred from the claim text.

Antibacterial and mineralizing compositions and methods of use thereof

Life of this patent

Antibacterial and mineralizing compositions and methods of use thereof

Life of this patent

Abstract

Claims16