5-membered heteroarylaminosulfonamides for treating conditions mediated by deficient CFTR activity

A compound of Formula (I):

• or a tautomer, or a pharmaceutically acceptable salt thereof,
• wherein:
• R1 is hydrogen or C1-6 alkyl;
• X is phenyl substituted with 0-3 occurrences of R2;
• Cy1 is phenyl substituted with 0-3 occurrences of R3;
• Cy2 is phenyl substituted with 1-3 occurrences of R4;
• each R2 is independently halo, —NH2, nitro, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, 4-10 membered heterocycloalkyl, 5-6 membered heteroaryl, C3-9 cycloalkyl, C3-9 cycloalkoxy, —C(O)NH2, —N(Ra)(R5), —N(Ra)C(O)—R5, —N(Ra)SO2—R5, —SO2—R5, —C(O)N(Ra)(R5), —S(O)—R5, —N(Ra)S(O)(NH)—R5 or —P(O)(R5)2, wherein each C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C3-9 cycloalkyl or 4-10 membered heterocycloalkyl is further substituted by 0-3 occurrences of R5;
• each R3 is independently halo, C1-8 alkyl, C1-8 alkenyl, C1-8 alkoxy, C1-8 haloalkyl, C1-8 haloalkoxy, C3-9 cycloalkyl, C1-4 alkyl-C3-9 cycloalkyl, C1-4 alkoxy-C3-9 cycloalkyl, C3-9 cycloalkoxy, C3-9 cycloalkenyl, 5-6 membered aryl, aralkyl, aralkoxy, 5-6 membered heteroaryl, 4-10 membered heterocycloalkyl, —C(O)—R7, —C(O)N(Ra)(R7) or —N(Ra)(R8), wherein each C3-9 cycloalkyl, C3-9 cycloalkoxy, C1-8 haloalkoxy, C1-6 alkoxy, 4-10 membered heterocycloalkyl, 5-6 membered aryl, 5-6 membered heteroaryl, cycloalkenyl, C1-4 alkyl-C3-9 cycloalkyl or C1-4 alkoxy-C3-9 cycloalkyl is further substituted with 0-3 occurrences of R7;
• each R4 is independently halo, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C3-6 cycloalkyl, N(Ra)2 or 4-10 membered heterocycloalkyl, wherein each 4-10 membered heterocycloalkyl may be further substituted with 0-3 Rb;
• each R5 is independently C1-6 alkyl, C1-6 haloalkyl, C3-9 cycloalkyl, hydroxyl, —SO2—R6, —CO2H, —NH2, —CO2—C1-4 alkyl or 4-10 membered heterocycloalkyl, wherein each C1-6 alkyl, C3-9 cycloalkyl or 4-10 membered heterocycloalkyl is further substituted by 0-3 occurrences of R6;
• each R6 is independently hydroxyl, —NH2, halo, C1-4 alkyl, C1-4 haloalkyl, —CO2H or —CO2—(C1-4 alkyl);
• each R7 is independently halo, C1-5 alkyl, C1-5 alkoxy, C1-5 haloalkyl, C1-5 haloalkoxy, C1-5 haloalkenyl, C3-7 cycloalkyl, hydroxyl, 5-6 membered aryl, aralkyl, aralkoxy, —C(O)—O—C1-4alkyl, —C(O)N(Ra)(C1-4 alkyl), 5-6 membered heteroaryl or 4-10 membered heterocycloalkyl, wherein each C3-7 cycloalkyl, 5-6 membered aryl or 4-10 membered heterocycloalkyl is further substituted by 0-3 occurrences of R8;
• each R8 is independently halo, C1-4 alkyl, C1-4 haloalkoxy, C(O)—C1-4 alkyl or C(O)N(Ra)(C1-4 alkyl);
• each Ra is independently H or C1-6 alkyl;
• and
• each Rb is C1-4 alkyl;
• wherein
• a) if Cy1 has 3 occurrences of R3, then each R3 is not methoxy;
• b) R2 and R4 are not each methyl;
• c) R3 and R4 are not simultaneously tert-butyl or simultaneously methoxy;
• and
• d) when Cy1 and Cy2 are mono-substituted, then R3 is not Cl and R4 is not OMe.