Back to results
US 12,752,016 B2Granted
Drug containing targeting liposomes
AssigneeNextage Therapeutics Ltd.
InventorJoseph Yeshayahu Klein
Life of this patent
Estimating the term…
Abstract
Described herein are novel, modified targeting peptides which can be incorporated within liposomes. Additionally, described herein are liposomes containing the modified targeting peptides. Liposomes preferably comprise a lipid-based bilayer and at least one drug. Also provided herein are methods for making the modified targeting peptides, and the liposomes, and methods for treatment of diseases of the CNS using the liposomes.
Claims17
A modified peptide having the structure:
- wherein R1 and R2 are each the same or different and are an alkyl chain having between 13 and 19 carbon atoms, R3 is a peptide having a sequence according to SEQ ID NO:1, wherein the methionine residue is oxidized in the form of sulfoxide and wherein R4 is a linker having the structure R6-R5-R7, wherein R6 and R7 are each independently a bond or a carbonyl group;
- and R5 is selected from the group consisting of:
- C1-20 straight alkyl, C3-20 branched alkyl, C3-20 cyclic alkyl, and C6-20 arylalkyl.
Dependencies are inferred from the claim text.