KRas G12D inhibitors

A compound of Formula (II):

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is hydrogen, hydroxy, halogen, C1-C3 alkyl, C1-C3 cyanoalkyl, C1-C3 hydroxyalkyl, HC(═O)—, —CO2R5, —C(O)N(R5)2 or a 5-6 membered heteroaryl;
• X is —C(O)—O—CH(R9)—O—C(O)—Z, —C(O)—O-aryl or —C(O)—C1-C6 alkyl;
• Y is a bond, O or NR5;
• Z is —(CH2)n—CH3 or C1-C3 alkyl;
• n is 0-20;
• R2 is hydrogen, —N(R5)2, heterocyclyl, C1-C6 alkyl, -L-heterocyclyl, -L-aryl, -L-heteroaryl, -L-cycloalkyl, -L-N(R5)2, -L-NHC(═NH)NH2, -L-C(O)N(R5)2, -L-C1-C6 haloalkyl, -L-OR5, -L-NR5C(O)-aryl, -L-COOH, or -LC(═O)OC1-C6 alkyl, wherein the heterocyclyl, the aryl portion of -L-NR5C(O)-aryl, the heterocyclyl portion of -L-heterocyclyl, and the cycloalkyl portion of the -L-cycloalkyl may be optionally substituted with one or more R6, and wherein the aryl or heteroaryl of the -L-aryl and the -L-heteroaryl may be optionally substituted with one or more R7;
• each L is independently a C1-C4 alkylene optionally substituted with hydroxy, C1-C4 hydroxyalkyl, heteroaryl or 1-2 deuterium;
• R3 is aryl or heteroaryl, wherein the aryl or the heteroaryl is optionally substituted with one or more R8;
• R4 is hydrogen, halogen or C1-C3 alkyl;
• each R5 is independently hydrogen or C1-C3 alkyl;
• each R6 is independently halogen, hydroxy, C1-C3 hydroxyalkyl, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, cyano, -Q-phenyl, -Q-phenylSO2F, —NHC(O)phenyl, —NHC(O)phenylSO2F, C1-C3 alkyl substituted pyrazolyl, araC1-C3 alkyl-, tert-butyldimethylsilyloxyCH2—, —N(R5)2, (C1-C3 alkoxy)C1-C3 alkyl-, (C1-C3 alkyl)C(═O), oxo, (C1-C3 haloalkyl)C(═O)—, —SO2F, (C1-C3 alkoxy)C1-C3 alkoxy, —CH2OC(O)N(R5)2, —CH2NHC(O)OC1-C6 alkyl, —CH2NHC(O)N(R5)2, —CH2NHC(O)C1-C6 alkyl, —CH2 (pyrazolyl), —CH2NHSO2C1-C6 alkyl, —CH2OC(O)heterocyclyl, —OC(O)N(R5)2, —OC(O)NH(C1-C3 alkyl)O(C1-C3 alkyl), —OC(O)NH(C1-C3 alkyl)O(C1-C3 alkyl)phenyl(C1-C3 alkyl)N(CH3) 2, —OC(O)NH(C1-C3 alkyl)O(C1-C3 alkyl)phenyl, —OC(O)heterocyclyl, —CH2heterocyclyl or deuterium, wherein the phenyl of —NHC(O)phenyl or —OC(O)NH(C1-C3 alkyl)O(C1-C3 alkyl)phenyl is optionally substituted with —C(O)H or OH and wherein the heterocyclyl of —CH2heterocyclyl is optionally substituted with oxo;
• Q is a bond or O;
• each R7 is independently, halogen, hydroxy, HC(═O)—, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 hydroxyalkyl, or —N(R5)2;
• each R8 is independently halogen, cyano, hydroxy, C1-C4 alkyl, —S—C1-C3 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C2-C4 hydroxyalkynyl, C1-C3 cyanoalkyl, triazolyl, C1-C3 haloalkyl, —O—C1-C3 haloalkyl, —S—C1-C3 haloalkyl, C1-C3 alkoxy, hydroxy C1-C3 alkyl, —CH2C(═O)N(R5)2, —C3-C4 alkynyl(NR5)2, —N(R5)2, deuteroC2-C4 alkynyl, (C1-C3 alkoxy)haloC1-C3 alkyl-, —O—C(O)—Z, or C3-C6 cycloalkyl wherein said C3-C6 cycloalkyl is optionally substituted with halogen or C1-C3 alkyl;
• and
• R9 is hydrogen or C1-C3 alkyl.