Mono- and bis-nitrosylated propanediols for therapeutic use

A method of treating a condition wherein NO has a beneficial effect, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula (I) indirectly to the pulmonary circulation and/or the systemic circulation of the patient:

• wherein R1, R2 and R3 each independently represent H or —NO,
• wherein n is 0 or 1;
• wherein when n is 0, R1 is H;
• and
• wherein when n is 1, R2 is H,
• provided that at least one of R1 R2 and R3 represents —NO,
• wherein the condition is selected from the group consisting of:
• acute pulmonary vasoconstriction of different genesis, pulmonary hypertension of different genesis, preclampsia, eclampsia, erectile dysfunction, acute heart failure (with or without preserved ejection fraction (HFpEF)), coronary heart disease, myocardial infarction, ischemic heart disease, angina pectoris, instable angina, cardiac arrhythmia, acute pulmonary hypertension in cardiac surgery patients, acidosis, inflammation of the airways, cystic fibrosis, COPD, immotile cilia syndrome, inflammation of the lung, pulmonary fibrosis, acute lung injury (ALI), adult respiratory distress syndrome, acute pulmonary oedema, acute mountain sickness, asthma, bronchitis, hypoxia of different genesis, ischemic disease of different genesis, stroke, cerebral vasoconstriction, inflammation of the gastrointestinal tract, gastrointestinal dysfunction, gastrointestinal complication, IBD, Crohn's disease, ulcerous colitis, liver disease, pancreas disease, inflammation of the bladder of the urethral tract, inflammation of the urinary bladder and ureters of the urethral tract, inflammation of the skin, diabetic ulcers, diabetic neuropathy, psoriasis, wound healing, organ protection in ischemia-reperfusion conditions, organ transplantation, tissue transplantation, cell transplantation, acute kidney disease, uterus relaxation, and cervix relaxation.