Treatment or prevention of ischaemic stroke reperfusion injury
AssigneeCambridge Enterprise Limited
InventorsMichael Patrick Murphy, Thomas Krieg
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Abstract
The present invention relates to salts and compositions for use in the treatment of ischaemic stroke reperfusion (IR) injury. In particular, the present invention relates to a salt of formula (I) for use in treating or preventing ischaemic stroke reperfusion injury, wherein X, Y, n, m, Z, A and B are as defined herein.
Claims19
A method of treating or preventing ischaemic stroke reperfusion injury in a subject, the method comprising administering a malonate salt of formula (II) to the subject:
- wherein X is selected from a negative charge, H, or C1-C12 alkyl;
- wherein Y is H;
- wherein Z is one or more pharmaceutically acceptable cations;
- and
- wherein A and B are independently any integer, such that the net charge of the salt is 0.
A method of treating or preventing ischaemic stroke reperfusion injury in a subject, the method comprising administering a composition to the subject, the composition comprising a salt of formula (II):
- in combination with one or more pharmaceutically acceptable excipients, carriers or diluents;
- wherein X is selected from a negative charge, H, or C1-C12 alkyl;
- wherein Y is H;
- wherein Z is one or more pharmaceutically acceptable cations;
- and
- wherein A and B are independently any integer, such that the net charge of the salt is 0.
Dependencies are inferred from the claim text.