3′3′ cyclic dinucleotides containing isonucleotidic units

A compound of formula (J):

• or an enantiomer, hydrate, solvate, or pharmaceutically acceptable salt or addition salt thereof,
• wherein
• Y1 and Y2 are each independently —O— or —CH2—;
• X1 and X3 are each independently OH, SH, OR15, or SR15,
• X2 and X4 are each independently O or S;
• RB1 is selected from Base′ and H,
• RB2 is selected from Base′ and H,
• wherein one of RB1 and RB2 is Base′;
• R1 is H or CN or F or Cl;
• R4 is H or OH or F;
• R6 is selected from H, CN, N3, F, Cl, COOR15, CON(R15)2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, OR15, SR15, and N(R15)2;
• each R15 is independently H, —C(═Z)R16, —C(═Z)OR16, —C(═Z)SR16, —C(═Z)N(R16)2, —CH2—Z—C(═Z)R16, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C2-C10 heterocycloalkyl, C6-C10 aryl, or C2-C10 heteroaryl;
• each R16 is independently H, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, C3-C7 cycloalkyl, C2-C10 heterocycloalkyl, C6-C10 aryl, or C2-C10 heteroaryl;
• preferably each R16 is independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C2-C10 heterocycloalkyl, C6-C10 aryl, or C2-C10 heteroaryl;
• each Z is independently O or S;
• Base′ and Base are each independently:
• wherein
• A1, A2, A3 and A4 are each independently H, OH, SH, F, Cl, Br, I, NH2, OR15, SR15, NHR15, N(R15)2, or R16, and
• wherein the C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C2-C10 heterocycloalkyl, C6-C10 aryl, or C2-C10 heteroaryl independently in each instance is optionally substituted with 1, 2, or 3 substituents independently selected from —OH;
• —SH;
• —NH2;
• —O;
• ═NH;
• —S;
• halogen;
• —N3;
• C6-C10 aryl optionally substituted with 1, 2, or 3 substituents independently selected from —OH, —CN, —O(C═O)ORB, —O(C═O)RB, and —COORB;
• unsubstituted C1-C6 alkyl;
• unsubstituted C1-C6 alkoxy;
• unsubstituted C1-C6 alkylthio;
• unsubstituted C1-C6 alkylamino;
• unsubstituted C1-C6 dialkylamino;
• —CN;
• —O(C═O)ORB;
• —O(C═O)RB;
• and —COORB;
• wherein RB is H or unsubstituted C1-C6 alkyl.