Electrophilic compounds and electrophilic prodrugs for treating aneurysm
AssigneesUniversity of Pittsburgh—Of the Commonwealth System of Higher Education, The Regents of the University of Michigan
InventorsFrancisco J. Schopfer, Bruce A. Freeman, Yang Zhao, Yuqing E. Chen, Jifeng Zhang
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Abstract
A method comprising administering to a subject having an aneurysm, suspected of having an aneurysm, or at risk of developing an aneurysm, a therapeutically effective amount of a compound selected from (i) a nitroalkene fatty acid, (ii) an unsaturated fatty acid having an electron withdrawing group, a leaving group, and a carbon-carbon double bond disposed between the electron withdrawing group and the leaving group, (iii) a thiolated nitro fatty acid, (iv) a dicarboxylic acid compound containing an electron withdrawing group, or a mixture of at least two of (i)-(iv).
Claims7
A method of treating an aneurysm, comprising administering to a subject a therapeutically effective amount of 10-nitro-octadec-9-enoic acid.
Dependencies are inferred from the claim text.