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US 12,723,246 B2Granted
Arc protein extracellular vesicle nucleic acid delivery platform
AssigneeUniversity of Massachusetts
InventorsVivian Budnik, James Ashley, Travis Thomson, Lee Fradkin
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Abstract
The present invention is related to the field of therapeutic delivery platforms. Such therapeutic delivery platforms are based upon the formation of proteinacous exovesicles that bind nucleic acid payloads (e.g., mRNA, siRNA, shRNA etc.). These nucleic acid payloads may hind to the proteinacous vesicle either directly or as an adduct of a linker molecule. As one example, the linker molecule may be an arc 3′UTR that is bound to an Arc protein exovesicle.
Claims7
An extracellular vesicle comprising:
- i) an encapsulated Drosophila activity-regulated cytoskeleton 1 (darc1) protein;
- ii) a nucleic acid comprising a fragment of a darc1 messenger ribonucleic acid 3′ untranslated region (darc1 mRNA 3′ UTR) that is the sequence of SEQ ID NO:
- 2 or SEQ ID NO 3 and bound to said darc1 protein;
- and
- iii) a non-arc nucleic acid payload fused to said nucleic acid of part (ii).
2 more elements
Dependencies are inferred from the claim text.