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US 12,721,986 B2Granted
Systems and methods for microneedle therapeutic delivery with acoustic signals
AssigneeThe Trustees of Indiana University
InventorsFeng Guo, Hongwei Cai, Junhua Xu
Life of this patent
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Abstract
Disclosed is a system for therapeutic delivery. The system includes a microneedle patch and an acoustic transducer configured to alter the delivery of the therapeutic from the patch. The acoustic parameters may be determined from a therapeutic release model. The system may also be contained within a housing which may be at least partially removed to deliver the therapeutic. The transducer provides control over the delivery of the therapeutic.
Claims15
A therapeutic delivery system comprising:
- a microneedle patch housing;
- a microneedle patch supported by the microneedle patch housing and comprising a first side and a second side;
- an array of microneedles is positioned on the first side of the microneedle patch, the array of microneedles containing a volume of a therapeutic;
- and
- an acoustic transducer coupled to the second side of the microneedle patch and configured to generate an adjustable acoustic signal with a plurality of acoustic parameters including a frequency, a duty cycle, an energy density, and a signal delivery time;
- wherein diffusion of the therapeutic from of the microneedle patch is controllable by altering at least one of the acoustic parameters, and at least one of the acoustic parameters is determined by a therapeutic release model configured to:
- calculate an acoustic field distribution;
- calculate a streaming field based on the acoustic field distribution;
- and
- calculate the at least one diffusion parameter based on the streaming field, wherein the at least one acoustic parameter is determined based on the at least one diffusion parameter.
7 more elements
A method of delivering a therapeutic comprising the steps of:
- at least partially removing a microneedle patch from a housing;
- positioning the microneedle patch on a surface such that a plurality of microneedles penetrate at least a portion of the surface;
- determining at least one acoustic signal parameter based on a therapeutic release model, the therapeutic release model configured to:
- calculate an acoustic field distribution;
- calculate a streaming field based on the acoustic field distribution;
- and
- calculate the at least one diffusion parameter based on the streaming field, wherein the at least one acoustic signal parameter is determined based on the at least one diffusion parameter;
- supplying power to an acoustic transducer coupled to the microneedle patch;
- generating an acoustic signal comprising the at least one acoustic signal parameter;
- applying the acoustic signal to the microneedle patch;
- delivering a volume of the therapeutic through the surface over a delivery time at a delivery rate;
- and
- controlling the delivery rate by altering the at least one acoustic signal parameter.
10 more elements
Dependencies are inferred from the claim text.