Methods of reducing ciliogenesis with alternating electric fields
AssigneeNovocure GmbH
InventorsMatthew R. Sarkisian, Lilach Avigdor, Preshita Desai
Life of this patent
Estimating the term…
Abstract
A method of determining susceptibility of cancer cells to treatment with alternating electric fields, or of reducing the viability of cancer cells by applying alternating electric fields, by measuring percentage of ciliated cancer cells or by measuring average length of a primary cilia of cancer cells. A method of treating Huntington's disease by applying alternating electric fields to a brain of a subject.
Claims19
A method of determining susceptibility of cancer cells of a subject to treatment with alternating electric fields, the method comprising:
- applying alternating electric fields to a first batch of cancer cells obtained or derived from a subject;
- after applying the alternating electric fields to the first batch of cancer cells ascertaining via imaging or RT-PCR or by determining a level of ARG13B or OTD1 a first percentage of the cancer cells of the first batch that are ciliated;
- ascertaining a second percentage of a second batch of cancer cells obtained or derived from the subject that are ciliated, wherein the second batch of cancer cells was not exposed to alternating electric fields prior to ascertaining the second percentage, wherein the first percentage of ciliated cancer cells is lower than the second percentage of ciliated cancer cells;
- and
- after ascertaining the first and second percentages of cancer cells that are ciliated, treating cancer cells of in the subject with alternating electric fields.
A method of reducing the viability of cancer cells of a subject, comprising:
- applying alternating electric fields to a first batch of cancer cells obtained or derived from a subject;
- ascertaining, after applying the alternating electric fields to the first batch of cancer cells, a first percentage of the cancer cells of the first batch that are ciliated;
- ascertaining a second percentage of a second batch of cancer cells obtained or derived from the subject that are ciliated, wherein the second batch of cancer cells was not exposed to alternating electric fields prior to ascertaining the second percentage, wherein the first percentage of ciliated cancer cells is lower than the second percentage of ciliated cancer cells;
- and
- after ascertaining the first and second percentages of cancer cells that are ciliated, applying alternating electric fields to the subject.
Dependencies are inferred from the claim text.