US 12,715,863 B2 · 5-(thiophen-2-yl)-1 H-tetrazole derivative as BCKDK inhibitors useful for treating various diseases

Abstract

Described herein are compounds of Formula I, wherein R1, R2, and R3 are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetes, NASH and heart failure.

Claims33

Dependent claims

A compound of Formula I

wherein
R1 is fluoro, chloro, amino, cyano, ethynyl, (C1-C4)alkyl, (C3-C4)cycloalkyl, (C1-C4)alkoxy, (C1-C4)fluoroalkyl or (C1-C4)fluoroalkoxy;
wherein when R2 is H and R3 is H, R1 is fluoro, chloro, amino, cyano, ethynyl, (C2-C4)alkyl, (C3-C4)cycloalkyl, (C1-C4)alkoxy, (C1-C4)fluoroalkyl or (C1-C4)fluoroalkoxy;
R2 is H, fluoro, chloro, bromo, hydroxyl, amino, cyano, ethynyl, (C1-C4)alkyl, (C3-C4)cycloalkyl, (C1-C4)alkoxy, C1-C4)fluoroalkyl, or (C1-C4)fluoroalkoxy;
and
R3 is H, fluoro, chloro, bromo, hydroxyl, amino, cyano, ethynyl, (C1-C4)alkyl, (C3-C4)cycloalkyl, (C1-C4)alkoxy, (C1-C4)fluoroalkyl or (C1-C4)fluoroalkoxy;
or a pharmaceutically acceptable salt of said compound.

4 more elements

Dependencies are inferred from the claim text.

5-(thiophen-2-yl)-1 H-tetrazole derivative as BCKDK inhibitors useful for treating various diseases

Life of this patent

5-(thiophen-2-yl)-1 H-tetrazole derivative as BCKDK inhibitors useful for treating various diseases

Life of this patent

Abstract

Claims33