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AssigneeLiv Process, Inc.
InventorsRonald J. Shannon, Michael McIntyre, Stefania Fabbri, Samantha Westgate
Estimating the term…
Embodiments of the present disclosure relate to a method of preventing and/or reducing C. difficile colonization of a surface. In certain embodiments, the aptamer can be used to kill and/or deactivate a C. difficile spore. In certain embodiments, the aptamer can be used to increase the sporicidal activity of a sporicidal agent. Embodiments of the present disclosure relate to the use of aptamers which specifically bind to C. difficile surface proteins, for example proteins located on the surface of a C. difficile spore.
A method for killing or inactivating Clostridioides difficile (C. difficile) spores, comprising contacting the spores with an agent selected from the group consisting of a sporicidal agent and a sporostatic agent;
A method for enhancing a sporicidal effect against C. difficile of a sporicidal agent, the method comprising contacting C. difficile spores with an aptamer capable of specifically binding to C. difficile spores and an agent selected from the group consisting of a sporicidal agent and a sporostatic agent, wherein the aptamer includes a nucleic acid sequence having at least 95% sequence identity with any one of the nucleic acid sequences as set forth in any of SEQ ID NOs:
Dependencies are inferred from the claim text.