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AssigneeInstitute of Microbiology, Chinese Academy of Sciences
InventorsFu Gao, Shuguang Tan, Dan Lu
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The present disclosure provides two specific T cell receptors targeting a G12V or G12C mutant epitope of a KRAS gene, and an anti-tumor use thereof. Each of the two T cell receptors consists of an α peptide chain and a β peptide chain. Further provided are an antigen binding fragment of the T cell receptors, a nucleic acid encoding the T cell receptors or an antigen binding fragment thereof, a vector comprising the nucleic acid, and a host cell comprising the vector. Further provided is a method for preparing a specific T cell receptor for a KRAS G12V mutation or an antigen-binding fragment thereof. The specific T cell receptor and antigen-binding fragment thereof can be used as an immune activator to stimulate an immune response of an organism, thereby generating an effect against tumors and other diseases.
A T cell receptor (TCR) or antigen-binding fragment thereof, capable of binding to a complex of KRAS-G12V8-16 epitope of SEQ ID NO:
Dependencies are inferred from the claim text.