Methods for initiating sotalol

A method of sotalol administration for treatment of one or more cardiac arrhythmias, comprising:

• determining a creatinine clearance of a subject prior to admission at a medical facility;
• receiving the subject for admission at a medical facility based at least in part on the creatinine clearance of the subject;
• determining a baseline QT or QTc interval and vital signs of the subject;
• administering to the subject an initial intravenous (IV) loading dose of sotalol hydrochloride over a period of up to 1 hour, wherein the IV loading dose is selected from an amount ranging from 60 mg to 125 mg responsive to determining the creatinine clearance of the subject;
• determining a second QT or QTc interval of the subject;
• determining that the second QT or QTc interval is within a selected range, wherein the selected range is less than about 500 msec or less than about 550 msec for ventricular conduction delay;
• administering oral sotalol hydrochloride to the subject responsive to determining the second QT or QTc interval is within the selected range including:
• administering a first oral dose of 40 mg to 160 mg after completion of the initial IV loading dose;
• and
• administering one or more subsequent oral dose(s) of 40 mg to 160 mg at about 12 hour, 24 hour, or 48 hour interval(s) after the first oral dose;
• and
• discharging the subject from the medical facility less than 10 hours after administering the initial IV dose, on a same calendar day.