Ionic polymers for medical device applications

A method of manufacturing a medical device, the method comprising:

• ionically bonding an ionic polymer and an active agent, and, optionally, a nonionic base polymer to form a body of the medical device, the body including the ionic polymer ionically bonded to the active agent, the ionic polymer comprising one or more of an anionic polymer, a cationic polymer, and a zwitterionic polymer,
• wherein the anionic polymer comprises a functional group selected from one or more of carboxylate (—COO—), sulfonate (—SO3—), organosulfate (—O—SO3—), organophosphate (—O—PO3—R1 or —O—PO32—), phenolate (—C6H4—O—), and thiolate (—S—),
• wherein the cationic polymer comprises a functional group selected from one or more of phosphonium (—P+(R1)(R2)(R3)), imidazolium, pyridinium, sulfonium, guanidinium, thiazolium, and quinolinium, or wherein the cationic polymer comprises two or more functional groups selected from quaternary ammonium (—N+(R1)(R2)(R3)), phosphonium (—P+(R1)(R2)(R3)), imidazolium, pyridinium, sulfonium, guanidinium, thiazolium, and quinolinium,
• wherein the zwitterionic polymer comprises two or more functional groups selected from carboxylate (—COO—), sulfonate (—SO3—), organosulfate (—O—SO3—), organophosphate (—O—PO3—R1 or —O—PO32−), phenolate (—C6H4—O—), thiolate (—S—), quaternary ammonium (—N+(R1)(R2)(R3)), phosphonium (—P+(R1)(R2)(R3)), imidazolium, pyridinium, sulfonium, guanidinium, thiazolium, and quinolinium, and
• wherein R1, R2, and R3 independently comprise hydrogen, halogen, alkyl, and aryl.