Grafted polymer and use thereof
AssigneeBausch + Lomb Ireland Limited
InventorsJames Anthony DiBella, Jr., Alok Kumar Awasthi, Jade J. Russell, Mark R. Mis, James Hauenstein, Mark Fornalik, Andrew J. Hoteling, Shawn M. Conlon, Kaushlendra Kumar
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Abstract
A grafted glycosaminoglycan polymer is disclosed. The grafted glycosaminoglycan polymer comprises a glycosaminoglycan having a polymer backbone and one or more side chains comprising a polyalkylene glycol-containing residue grafted onto the polymer backbone.
Claims20
A biomedical device having a coating on a surface thereof, the coating comprising a grafted glycosaminoglycan polymer,
- wherein the grafted glycosaminoglycan polymer is a reaction product of (a) a glycosaminoglycan having a polymer backbone containing reactive functionalities;
- and (b) a polymer comprising polyalkylene glycol chains and at least one reactive end group complementary to at least one of the reactive functionalities of the polymer backbone of the glycosaminoglycan;
- wherein the at least one reactive end group of the polymer forms one or more side chains comprising a polyalkylene glycol-containing residue grafted onto the at least one of the reactive functionalities of the polymer backbone of the glycosaminoglycan, wherein the reaction product is derived from (i) activating the glycosaminoglycan in a solution comprising one or more catalysts with an activator comprising one or more epoxyamines;
- and (ii) grafting the one or more side chains comprising the polyalkylene glycol-containing residue onto the at least one of the reactive functionalities of the polymer backbone of the glycosaminoglycan by sequentially or simultaneously adding a polyol and an epoxyalcohol to the activated glycosaminoglycan;
- and
- wherein the biomedical device is a contact lens or an intraocular lens.
A packaging system for the storage of an ophthalmic device comprising a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising a grafted glycosaminoglycan polymer comprising a glycosaminoglycan having a polymer backbone and one or more side chains comprising a polyalkylene glycol-containing residue grafted onto the polymer backbone, wherein the aqueous packaging solution has an osmolality of at least about 200 mOsm/kg, a pH of about 6 to about 9 and is sterilized.
A method of preparing a package comprising a storable, sterile ophthalmic device, the method comprising:
- (a) immersing an unused ophthalmic device in an aqueous packaging solution comprising a grafted glycosaminoglycan polymer comprising a glycosaminoglycan having a polymer backbone and one or more side chains comprising a polyalkylene glycol-containing residue grafted onto the polymer backbone, wherein the aqueous packaging solution has an osmolality of at least about 200 mOsm/kg and a pH in the range of about 6 to about 9;
- (b) packaging the aqueous packaging solution and the unused ophthalmic device in a manner preventing contamination of the unused ophthalmic device by microorganisms;
- and
- (c) sterilizing the packaged aqueous packaging solution and the unused ophthalmic device.
Dependencies are inferred from the claim text.