Hydrophobically modified chitosan compositions
AssigneeMedcura, Inc.
InventorMatthew Dowling
Life of this patent
Estimating the term…
Abstract
Disclosed herein is a polymer composition comprising an effective amount of a hydrophobically-modified polymer having functional groups along the backbone occupied by a fatty acid anhydride moiety. The polymer composition has a potent hemostatic action by gelling blood upon contact, and is suitable for treating internal and external bleeds. As disclosed herein, the modified polymer can be generated without the use of toxic reagents that would require removal from the product. Further, compositions are shelf stable even in a flowable form. That is, the hydrophobic grafts are not lost under product storage conditions (e.g., room temperature storage).
Claims20
A polymer composition comprising an effective amount of a hydrophobically-modified chitosan, the hydrophobically-modified chitosan having hydrocarbon groups attached to the chitosan backbone through amide linkages, wherein the composition is formulated with a pH of about 5 or less and is in the form of a gel, film, powder, foam or putty,
- wherein the hydrophobic groups comprise C1 to C4 hydrocarbon groups and a hydrocarbon greater than C6, and
- wherein the C1 to C4 hydrocarbon groups are present at 20 mol % to 40 mol % with respect to amine groups of chitosan.
Dependencies are inferred from the claim text.