Continuous bioprocessing centrifuge rotor

A rotor assembly for centrifuging liquid media, comprising:

• a bio-process bag including a lower portion and an upper portion, the upper portion of the bio-process bag including an axially-aligned neck connected to the lower portion of the bio-process bag and a radially-aligned skirt that extends outward from the axially-aligned neck;
• a drum including a first base having an outer rim and a first circumferential wall that extends upward from the outer rim, the first circumferential wall including a first outer surface and a first inner surface, the first inner surface defining a first opening that receives the lower portion of the bio-process bag,
• wherein the drum includes a plurality of axially-aligned baffles and wherein the lower portion of the bio-process bag includes a plurality of interior pockets and a plurality of exterior pockets each located between two adjacent interior pockets, each of the exterior pockets being configured to engage a respective one of the axially-aligned baffles of the drum,
• a pressure ring including a first radially-aligned flange and a second circumferential wall, the first radially-aligned flange including a first upper surface, an outer edge, and an inner edge that defines a second opening, the second circumferential wall extending downwardly from the outer edge and having a second inner surface that engages the first outer surface of the first circumferential wall of the drum;
• and
• a holder including a third circumferential wall having an outwardly-facing surface and a second radially-aligned flange having a first lower surface, the second radially-aligned flange extending outwardly from an upper portion of the third circumferential wall, at least one of the outwardly-facing surface and the first lower surface operatively coupling the upper portion of the bio-process bag to the pressure ring.