US 12,623,092 B2 · Dynamic adaptation of radiotherapy treatment plans

Abstract

A reference radiotherapy treatment plan having a plurality of control points, such as a sequence of gantry angles, aperture leaf positions, and intensity weights, can be adapted during the radiotherapy treatment session. Treatment imaging data of a patient may be obtained during the radiotherapy treatment session and one or more parameters may be determined using the treatment imaging data. Then, a current radiotherapy treatment plan may be generated based on the parameter(s). The reference radiotherapy treatment plan for the radiotherapy treatment session may be modified during the radiotherapy treatment session by updating one of the plurality of control points of the reference radiotherapy treatment plan with a control point of a current radiotherapy treatment plan, which may compensate for patient deformations during the delivery of radiotherapy treatment, or intrafraction patient deformations and thereby improve the delivery accuracy and efficacy of radiation doses to a patient undergoing radiotherapy treatment.

Claims27

Dependent claims

A computer-implemented method for adaptation of a reference radiotherapy treatment plan having a plurality of control points, performed on a subject in a radiotherapy treatment session, the computer-implemented method comprising:

obtaining treatment imaging data of the subject during the radiotherapy treatment session;
determining at least one parameter using the treatment imaging data;
generating a current radiotherapy treatment plan based on the at least one parameter;
modifying the reference radiotherapy treatment plan for the radiotherapy treatment session during the radiotherapy treatment session by updating one of the plurality of control points of the reference radiotherapy treatment plan with a control point of the current radiotherapy treatment plan;
and
using a trained model that includes:
generating at least two training images representing potential anatomical states of the subject, the at least two training images corresponding to at least two training parameters:
generating at least two training radiotherapy treatment plans corresponding to the at least two training images;
and
generating a training regression between the at least two training parameters and the at least two training radiotherapy treatment plans.

7 more elements

A radiotherapy system for adaptation of a reference radiotherapy treatment plan having a plurality of control points, performed on a subject in a radiotherapy treatment session, the radiotherapy system comprising:

an image acquisition device configured to acquire measurements of the subject during the radiotherapy treatment session;
a processor configured to:
perform, at a first rate, a first computational loop to generate at least one parameter using the acquired measurements, wherein the at least one parameter represents an anatomical state of the subject;
perform, at a second rate that is independent of the first rate, a second computational loop to generate a current radiotherapy treatment plan based on the at least one parameter, wherein the current radiotherapy treatment plan includes a plurality of control points;
and
modify a reference radiotherapy treatment plan for the radiotherapy treatment session during the radiotherapy treatment session by updating a control point of the reference radiotherapy treatment plan with the control point of the current radiotherapy treatment plan;
and
a radiotherapy device configured to deliver a dose of radiation to an anatomical region of interest using the current radiotherapy treatment plan.

5 more elements

Dependencies are inferred from the claim text.

Dynamic adaptation of radiotherapy treatment plans

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Dynamic adaptation of radiotherapy treatment plans

Life of this patent

Abstract

Claims27